Sunday, December 29, 2019

Molecular Mechanisms Underlying Aging Associated Decline

Molecular Mechanisms Underlying Aging Associated Decline in Memory Storage Cognitive function depends on proper wiring and functional connections within neuronal circuits. Despite advances in understanding human aging and aging-associated cognitive decline, molecular and cellular mechanisms underlying aging associated impairments in learning and memory are still poorly understood. In particular, very little is known about whether physiological and molecular changes in identified neurons that are important for learning lead to aging associated decline in long-term memory storage. We approach this problem by delineating the aging associated changes in two well characterized neurons, presynaptic LE sensory neurons (LESNs) and postsynaptic L7 motor neuron (L7MN) of Aplysia whose normal functioning is critical for the learning of gill withdrawal reflex (GWR). Along with us, others have used Aplysia as a model to understand aging associated changes in neuronal physiology, response to neur otransmitters, gene expression and behavioral learning. In a study that examined electrophysiological and gene expression changes in identified neuron R15 of Aplysia, we recently described specific changes in burst firing and action potentials, expression of several genes in R15 during aging and specific changes in the expression of key regulators of transcription and translation in four identified neurons (L7, L11, R2, R15) of Aplysia. The long-term goal of this project is to identify synapticShow MoreRelatedFunctional Connections Within Neuronal Circuits839 Words   |  4 Pagesadvances in understanding human aging and aging-associated cognitive decline, molecular and cellular mechanisms underlying aging associated impairments in learning and memory are still poorly understood. In particular, very little is known about whether physiological and molecular changes in identified neurons that are important for learning lead to aging associated decline in long-term memory storage. We approach this problem by delineating the aging associated changes in two well characterizedRead MoreThe World Population Is Evolving Ageing And Cognitive Impairment ( Ci ) Is A Fast Growing Problem1722 Words   |  7 PagesMaintaining productivity beyond 60 years old depends, in large part, on maintaining a level of cognitive ability that allows a person to continue to interact effectively and appropriately with the environment. Cognitive decline is becoming a more prevalent, frightening, and expensive personal and social problem – but a problem that companies can more effectively address with innovative products and services. The world population is rapidly ageing and cognitive impairment (CI) is a fast growing problemRead More Does Exercise Help the Brain? Essay examples1735 Words   |  7 Pagesbother working out? The reasons to work out may be greater than you think. Physical activity can make you feel good, keep you in shape, keep you healthy, but now researchers also are finding biological evidence that exercise benefits specific brain mechanisms. Just as exercise improves muscle tone and function, it may also have similar effects on the brain. Some people have thought that exercise positively affects the brain as well as the body. Preliminary evidence suggests that physically activeRead MoreDevelopment Of The Mammary Gland9524 Words   |  39 Pageshappen during the aging. Several risk factors with various degree of risk have been demonstrated such as late pregnancy, late menopause, obesity, radiation exposure, family history of cancer et al. Breast cancer incidence increases with age but all women are at risk. Breast cancer is also more common in certain races including Caucasian, African-Americans. Certain genetic abnormalities are also associated with breast cancer and will be further discussed in the section of molecular feature of breastRead MoreEssay Parkinsons Disease3763 Words   |  16 Pages(manganese, carbon monoxide, carbon disulfite, etc.). Parkinson’s can also result from arteriosclerotic brain disease, syphilis, and brain tumors. All of the above known causes however, are secondary to idiopathic P arkinson’s Disease, to which the underlying cause is not yet known. Nevertheless, extensive research has constructed a plausible set of criteria which in effect has defined the pathological onset. PD can be characterized by two distinguishing features: morphologically, by the appearance ofRead MoreAlzheimer s Disease : A Progressive Degenerative Disease2632 Words   |  11 Pagesanalysis. When he was inspecting the brain, he came to notice the neurons had thick, strongly staining fibrils. Moreover, the cortex was full of plaques of unknown composition. Auguste D’s brain thus showed the histological features that are today associated with Alzheimer’s disease: the massive loss of neurons and the presence of amyloid plaques and neurofibrillary tangles. On November 3rd 1906 Alzheimer first reported his findings and introduced the world officially of this disease (Berrios , 2004)Read MoreSocm Study Guide Essay30404 Words   |  122 Pagescommunication, control * Defense -Proteins are chains of small inorganic molecules called amino acids Nucleic acid – large organic molecules composed of carbon, H, O2, N, and phosphorous. * Nucleic acid store and process information at the molecular level inside living cells * 2 types, RNA and DNA * DNA determines our inherited characteristics * RNA cooperate to manufacture specific proteins using the info provided by DNA * Nucleic acid is made up of nucleotides. A singleRead MoreCommunity Acquired Pneumonia18251 Words   |  74 Pagespain or discomfort, myalgia, headache, chills, fever, cough, tachycardia, tachypnea, and sputum production. Severe chest muscle weakness may also be present. Crackles or wheezes are heard upon auscultation. (Ignatavicius, 2006) Some people have an underlying problem which increases their risk of getting an infection. Chronic lung disease, compromised immune system, corticosteroids or other medications that suppress the immune system, swallowing disorders, smoke and environmental pollutants, and drugRead MoreFlx Case Study6827 Words   |  28 Pagesmost widely used antidepressants for the treatment of de- pression and anxiety associated with AD, however, it is unknown if the drug affects the pathogenesis of the disease. We showed that FLX improved spatial memory, learning and emotional behaviors of APP/PS1 mice, a well characterized model of AD. In the same mice, FLX effectively prevented the protein loss of synaptophysin (SYP) and microtubule- associated protein 2 (MAP2). FLX was unable to prevent plaque formation, but significantlyRead MoreMerck Case18783 Words   |  76 Pagesparticipating in the growth in healthcare services. This means understanding the industry requires appreciating its political economic context. In this regard, healthcare providers in rich nations are currently under pressure to control costs due to aging populations. Regulators who have the authority to change the demand structure through laws and regulations are considering various measures to reduce costs such as generic drug substitution which may mean lower returns for discovering and developing

Saturday, December 21, 2019

Digital Britain Report And Un Egovt - 981 Words

ISEM 500; Homework 4 Sushma Thoutam (Student ID # ) Text Chapter Highlights Relationship to Digital Britain Report and UN eGovt Site Topic (Strategy and eBusiness) -- Chapter two and Three: Highlights (5 key ideas, one sentence each) 1. Key idea is to put forward Digital technology mainly Internet that is important to most of the people these days. It empowers business processes to implement business strategy for digital enterprises. 2. Describes massive profits brought by technology revolution in the recent years. 3. A strong representation on market dynamics has been explained how a business organizes an establishing strategy by Porter’s Model. 4. Parts of the chapters provide a description of how the internet, web, and information and communication technologies have evolved in past years. 5. Making the web and internet technologies fundamental to business developments makes avenues for better communication between stakeholders. Relationship to Digital Britain Report The term Digital Britain is advancing for the great nation to prepare itself for the challenges in the coming generations. It also refers to a picture where internet technology, communication, and information are combined into how businesses operate. Topic (Ethical Issues) -- Chapter Four: Highlights (5 key ideas, one sentence each) 1. This chapters highlights the issues concerning to unethical usage of information more than limited. Many strategies have been suggested to get rid of

Thursday, December 12, 2019

Operating System for Engineering and Technology- myassignmenthelp

Question: Discuss about theOperating System for Engineering and Technology. Answer: Background The upgrades of Windows 10 are available automatically to the user who is using Windows 7 or Windows 8. The FSET (The Faculty of Science, Engineering and Technology) in Swinburne University of Technology has planned to upgrade the operating environment from Windows 7 to Windows 10 in all its computer laboratory rooms. To upgrade its Windows from 7 to 10, the FSET has to go through different steps for upgrading its operating system. Steps to be followed prior to Installing Windows 10 Before upgrading all the system in a computer laboratory, some points are to be kept in mind. Firstly there should be enough space in the system to install and upgrade Windows 10. Half of the hard drive in all the systems should be kept to upgrade Windows 10 from Windows 7 without loss of any data or program files (Wash et al. 2014). Minimum of free space of 20GB is to be kept empty in each of the system having 64 bit version. Some information such as accounts information, login id, login passwords and all the similar type of details are lost for the upgradation of Windows 10. If the systems that are used in laboratories are old modeled, then the systems must install all the drivers that are required by Windows 10 to cover the hardware components. Drivers must be included in Windows 10 that supports all the hardware components that are available in the market (Cline et al. 2014). The system must have all backup done before starting the upgrade. When upgrade is available in the system , the system shows popup automatically. All the personal files of the systems should be kept as backup to an external storage and also make a full system backup in all the systems using a built-in tool known as System Image Backup Tool (Chuchro et al. 2015). The upgrading system of Windows 10 is very straightforward. All these backups are to be kept for safety purpose. The next step that is to be kept in mind before upgrading a system to Windows 10 is that if antivirus is installed in the system, then it must be uninstalled or should be made disabled. All other software that provides security to system should be disabled or is uninstalled. Only the hardware peripherals such as mouse, keyboard and monitor should be connected to the systems in the laboratory (Ying, Xin and He 2014). All the applications that are not used and those applications that are listed by Get Windows 10 should be uninstalled. These peripherals creates problem for installing Windows 10 in the systems. These are done automatically by the application known as Get Windows 10. This app will scan the full system for application compatibility. If there exists issue that prevents the system from upgradation, then the list of application that prevents the upgrading system is notified on the screen. If it as accepted, all the application that prevents the upgrading process will be remov ed from all the system before upgrade. Before removing the applications all the list must be noted (Belhaiza, Hansen and Laporte 2014). The Microsoft applications that are standard and all the common software are preserved. Older version of Microsoft Office, some tax and accounting software, games, third party applications and custom applications can develop some issues after upgrading Windows 10 or may top working. To have complete successful installation of Windows 10, backup of the system should be done before installation process and restore process should be done after the installation is complete. Before starting upgrade process, all the files and applications are to be securely backed up. Process if Installing and Upgrading Windows 10 After the system is fully backed up, then the system is ready to install Windows 10. From the computer, Upgrade this PC now is selected to start upgrade process and then Next is clicked. The process of downloading begins when next is clicked. The downloading depends on the internet speed that all the system of the lab is connected with. When the downloading is finished, to unpack the installation process, terms of license agreement should be accepted and final update is to be done by the installer and a final checking of the update is done before the arrival of the confirmation page (Zhang, Xu and Jia 2014). Then a page will arrive showing three option for Choose what to keep. In this section the option is selected on what kind of installation is needed by FSET. This section helps to keep the personal files and applications in the system that were kept as backed up. Then click next to precede the installation process. The final screen will return after the next is clicked (Manen, Gui llaumin and Van Gool 2013). The system will reboot as per the instruction of installer and then the login screen of the windows will appear. For first time log in, the screen will show to accept Express Settings and then click to Customize Settings. The first screen that comes is the personalization screen. In this screen the privacy conscious is to be turned off. The second screen that comes is the browser protection, error reporting and hotspots. If the system uses Windows Store or Microsoft Edge, then SmartScreen is very much useful. The browsing data is sent to Microsoft. The Final screen shows the Windows apps for web browsing, movies, music or photos. After clicking next, the screen will be taken to Windows 10. After installing Windows 10 After the installation process, the apps that were backed up should be checked weather they exist or not. All the peripherals should be plugged in and checked if all are working correctly (Nelson, Phillips and Steuart 2014). The drivers should be updated if it is necessary and final installation and upgradation to Windows 10 is done. After the installation process, all the applications and files are present in the system. A software known as Zinstall can be used to restore all the backups automatically to the system. Once the backup process is done, then the Windows is ready to use. References Belhaiza, S., Hansen, P. and Laporte, G., 2014. A hybrid variable neighborhood tabu search heuristic for the vehicle routing problem with multiple time windows.Computers Operations Research,52, pp.269-281. Chuchro, M., Lupa, M., Pi?ta, A., Pirkowski, A. and Le?niak, A., 2015. A concept of time windows length selection in stream databases in the context of sensor networks monitoring. InNew trends in database and information systems II(pp. 173-183). Springer, Cham. Cline, J.M., Dupuis, G., Liu, Z. and Xue, W., 2014. The windows for kinetically mixed Z-mediated dark matter and the galactic center gamma ray excess.Journal of High Energy Physics,2014(8), p.131. Manen, S., Guillaumin, M. and Van Gool, L., 2013. Prime object proposals with randomized prim's algorithm. InProceedings of the IEEE international conference on computer vision(pp. 2536-2543). Nelson, B., Phillips, A. and Steuart, C., 2014.Guide to computer forensics and investigations. Cengage Learning. Wash, R., Rader, E., Vaniea, K. and Rizor, M., 2014, July. Out of the loop: How automated software updates cause unintended security consequences. InSymposium on Usable Privacy and Security (SOUPS)(pp. 89-104). Ying, X., Xin, S.Q. and He, Y., 2014. Parallel Chen-Han (PCH) algorithm for discrete geodesics.ACM Transactions on Graphics (TOG),33(1), p.9. Zhang, Q., Xu, L. and Jia, J., 2014. 100+ times faster weighted median filter (WMF). InProceedings of the IEEE Conference on Computer Vision and Pattern Recognition(pp. 2830-2837).